In this study, we demonstrate that SPINK1 protein and mRNA levels correlate and that low SPINK1 expression in tumor tissue is indicative of poor prognosis, in line with our previously published results (Koskensalo et al., 2012) and with a recent publication (Chen et al., 2016) in which high SPINK1 tumor expression correlated with a good prognosis in patients with CRC receiving cetuximab therapy. This evidence concerns the gene SPINK1 and neoplasm.