We focused on lunatic fringe (LFNG) that encodes for a glycosylating enzyme (O‐fucosylpeptide 3‐beta‐N‐acetylglucosaminyltransferase) that regulates NOTCH signalling (Moloney et al., 2000), and show an important role for this gene in controlling melanoma metastasis. This evidence concerns the gene LFNG and melanoma.