KDM5B and neoplasm: Examples for biological heterogeneity include switching between proliferative and invasive states (Hoek et al. 2008), variable expression of tumor-associated antigens (Slingluff et al. 2000) as well as dynamic expression of CSC markers including CD133 (Shackleton et al. 2009), ABCB5, NGFR (Quintana et al. 2010) or KDM5B (Roesch et al. 2010).