When activated, platelets express CD154 and release a soluble form of CD154 [22, 210]; CD154 may bear a particular responsibility as, for example, the CD154/CD40 dyad plays a deleterious role in ALI, including pancreatitis-associated lung injury [211, 212], and as it could be brought to lung microcirculation via PMPs. The gene discussed is CD40LG; the disease is acute respiratory distress syndrome.