In hopes of restoring sight, a number of approaches have conferred light sensitivity to these remaining cells in animal models of RP, such as the rd1 mouse, by expressing light-sensitive signaling proteins, including microbial ion channels and pumps6–10, chemically engineered receptor-channels11, 12 and photo-chemicals that sensitize native ion channels13–17. Here, PDE6B is linked to retinitis pigmentosa 1.