In contrast to the early exaggeration of cardiac inflammation and remodelling induced by the deficiency of annexin-A1 after 8 days MI (a phenomenon that drives ventricular dysfunction), by 4 weeks after MI, the majority of these pro-inflammatory and remodelling responses were no longer significantly affected by genotype (Fig. 8c–l). The gene discussed is ANXA1; the disease is myocardial infarction.