To elucidate the mechanism of liver pathology in schistosomiasis, here we investigated the dynamics of Tfh cell proliferation and phenotypes in mice infected with S. japonicum. As shown in Fig. 1d–g, the percentages of CXCR5+ CD4+ Tfh cells in the splenic lymphoid cells were elevated at 4 weeks post-infection and reached a plateau by 12 weeks post-infection. This evidence concerns the gene CD4 and schistosomiasis.