CD4 and schistosomiasis: Using the mice model of schistosomiasis, the present study also indicated that Bcl-6+CD4+ cells would express higher CXCR5 of Tfh marker molecules than Bcl-6−CD4+ cell, the ability of Bcl-6 to up-regulate the expression of CXCR5 was strengthened in mice following S. japonicum infection.