Regarding to metabolism characterization, A549 cell line showed a more OXPHOS metabolism, with higher Gal/Glc index, greater oxygen consumption, lower glucose consumption, elevated levels of PGC-1alpha and lower levels of GAPDH/MT-CO1, whereas the tumor cell lines H1299 and H460 turned out to be more glycolytic, with lower Gal/Glc index, lower oxygen consumption, greater consumption of glucose, reduced levels of PGC-1alpha and elevated GAPDH/MT-CO1 ratio. This evidence concerns the gene PPARGC1A and neoplasm.