Thus, the correlation of inflammatory proteins and RNA binding proteins in the M6 and M2 modules, respectively, to clinical and pathological traits, may represent a molecular pathophysiological connection between TDP‐43 proteinopathy, related post‐translational modifications, and consequent changes in the brain proteome occurring along the ALS‐FTD disease spectrum. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.