The strong enrichment of TDP‐43 interactors and other causal genes for ALS within M2 and M6 modules further reinforces their association with the ALS/FTD spectrum and suggests that proteins within these modules have critical roles in mechanisms that drive TDP‐43 aggregation and other cellular‐driven pathological processes (i.e., neuroinflammation). This evidence concerns the gene TARDBP and frontotemporal dementia.