M2 showed a strong correlation with clinical and pathological traits of cases on the ALS/FTD spectrum, co‐expressed with protein products of genes with causative links to ALS (hnRNPs, matrin 3, profilin 1, and TDP‐43) and had significant enrichment of TDP‐43 PPIs. Here, PFN1 is linked to amyotrophic lateral sclerosis.