Two astrocytic proteins (GFAP, HEPACAM) and two microglial proteins (MSN and TPP1) with high kME were confirmed to be increased in abundance in frontal cortex homogenates from FTD cases compared to that of control and ALS cases by Western blot analysis (Figs 5B and EV4A and B). This evidence concerns the gene TPP1 and frontotemporal dementia.