Importantly, this new insight will not only provide a paradigm for understanding how this pathway can be perturbed in rare conditions, such as CAMT, but will also provide insights into approaches to modulate this signaling pathway for treating more common conditions, such as idiopathic aplastic anemia, where MPL agonists are already showing efficacy (Townsley et al, 2017). Here, MPL is linked to idiopathic aplastic anemia.