The genomic region in the ITU lies within the transcription elongation regulator 1 like (TCERG1L) gene that has been associated with regulation of plasma levels of the adipokine adiponectin [213], a modulator of glucose regulation and fatty acid oxidation [214] implicated in obesity, diabetes, coronary artery disease and Crohn’s disease risk [215–217]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.