Also, the pooled data of 3 studies showed that high Ezrin expression was significantly associated with distant metastasis in colorectal cancer (OR = 3.06, 95% CI = 1.77–5.31, P = 0.000), where no significant heterogeneity among studies was noted (I2 = 0.0%, P = 0.530) (Figure 5B). The gene discussed is EZR; the disease is colorectal cancer.