The pooled data of 4 studies showed that high Ezrin expression was not significantly associated with tumor grade in esophageal cancer (OR = 1.26, 95% CI = 0.82–1.93, P = 0.290), where no significant heterogeneity among studies was observed (I2 = 0.0%, P = 0.982) (Figure 2C). The gene discussed is EZR; the disease is esophageal cancer.