Second, the pooled data from 4 studies showed that high Ezrin expression was significantly associated with the TNM stage of gastric cancer (OR = 4.69, 95% CI = 1.38–15.89, P = 0.013), but the heterogeneity among these 4 studies was significant (I2 = 90.6%, P = 0.000) (Figure 3A). This evidence concerns the gene EZR and gastric cancer.