EZR and gastric cancer: Third, the pooled data from 6 studies showed that high Ezrin expression was significantly associated with lymph node metastasis in gastric cancer (OR = 3.96, 95% CI = 1.47–10.70, P = 0.007), with significant heterogeneity among studies (I2 = 85.0%, P = 0.000) (Figure 4A).