Third, the combined data of 3 studies showed that high Ezrin expression was significantly associated with lymph node metastasis in colorectal cancer (OR = 9.52, 95% CI = 3.93–23.02, P = 0.000), with no significant heterogeneity among studies observed (I2 = 0.0%, P = 0.902) (Figure 4B). The gene discussed is EZR; the disease is metastatic malignant neoplasm in the lymph nodes.