First, the pooled data of 5 studies showed that high Ezrin expression was significantly associated with tumor grade in colorectal cancer (OR = 3.94, 95% CI = 2.10–7.38, P = 0.000), where no significant heterogeneity among studies was observed (I2 = 0.0%, P = 0.446) (Figure 2B). The gene discussed is EZR; the disease is colorectal cancer.