We determined (i) p53 immunoreactivity and the proliferation marker Ki-67 to identify VSCCs arising in the setting of lichen sclerosus et atrophicus [23]; (ii) high risk HPV and p16INK4a (a marker of HPV-transforming activity) to identify VSCCs driven by viral infection [24]. The gene discussed is TP53; the disease is lichen sclerosus et atrophicus.