IL32 and Miyoshi myopathy: As shown in Figure 7D and 7E, IL-32-knockdown RPMI8226 cells and OPM2 cells showed a lower proliferation rate in the imitated BM microenvironment compared to normal MM cells (e.g., RPMI8226, 72 h,7.24±0.20 vs 8.82±0.34, p<0.05); when rIL-32α (40ng/mL) was applied to rescue the IL-32-knockdown MM cells in the co-culture system, the proliferation rate increased again (e.g., RPMI8226, 72 h,8.62±0.26 vs 7.24±0.20, p<0.05).