There was a small but significant (P=0.0169) increase in ERK phosphorylation in response to auranofin in HPDE-Kras cells and similar to KC cells in Figure 4, a significant decrease in AKT phosphorylation in HPDE and Panc1 cells (P=0.0493 and 0.0211 respectively) (See Supplementary Figure 8A). This evidence concerns the gene AKT1 and keratoconus.