PRDX1 and keratoconus: The presence of this p100 Prdx1 in KC mice and the unresponsiveness of p40 Prdx1 to auranofin suggests that Prdx1 in cells from KC mice has an altered ability to oligomerize (which is also associated with an inability to respond to redox stimuli), despite there being some Txn expression in normal acinar cells in primary culture.