RARRES2 and ovarian cancer: Chemerin (RARRES2 [retinoic acid receptor responder 2] and TIG2 [tazarotene induced gene 2]) [6], is purified from the ascetic fluids of ovarian cancer patients and has been shown to be a natural ligand for G protein-coupled receptor-1 (GPR-1) and chemokine C-C motif receptor-like-2 (CCRL-2) [7, 8].