VWF and paroxysmal nocturnal hemoglobinuria: Considered the level of vWF and factor VIII may be affected by the function of platelets and endothelial cells, and intravascular hemolysis is the most important factor for the activation of platelets and endothelial cells in PNH [6], we detected the correlation between the PNH clone, LDH level (correlated with intravascular hemolysis), platelet counts, and the level of vWF and factor VIII in patients with PNH, and found no significant correlations (Supplementary Figure 1).