Further, the PNH cohort had significant higher plasma levels of vWF and factor VIII compared with normal controls (vWF:Ag: 156±47 IU/dl vs. 127±45 IU/dl, P=0.039; VIII: C: 176±57% vs. 129±50%, P=0.005, respectively; Figure 3). This evidence concerns the gene VWF and paroxysmal nocturnal hemoglobinuria.