GLI1 and neoplasm: During EMT process, a great deal of cancer signaling pathway, such as TGF-β, NOTCH, Wnt, PI3K-Akt all have crosstalk with Hedgehog (HH)/glioma-associated oncogene homolog (GLI) pathway and the interaction among these signaling pathway plays pivotal roles for the induction of EMT and tumor aggressiveness [15].