PTTG1 which expressed at very undetectable or low level in normal tissues, was shown to be highly expressed in a variety of cancers tissues: colorectal, ovarian, breast, colon and esophagus, what's more its expression was also associated with lymph node metastasis [9–12]. The gene discussed is PTTG1; the disease is metastatic malignant neoplasm in the lymph nodes.