ERBB4 and glioblastoma: As shown in Figure 3B and Table 6, we found that CNG of the above genes had very little effect on the survival of the patients with GBM, while CNG of EGFR (40.2 months vs. 71.4 months, P =0.001), HER3 (44.8 months vs. 58.2 months, P =0.02) and HER4 (46.2 months vs. 57.7 months, P =0.03) significantly shortened median survival times of the patients with LGG.