Similar to the findings from univariate analysis, CNG of EGFR (OR =9.61, 95% CI =2.83-32.7, P <0.001), HER3 (OR =4.47, 95% CI =1.35-14.75, P =0.01) and HER4 (OR =5.07, 95% CI =1.50-17.06, P =0.009) was still significantly associated with cancer-related death in glioma patients (Table 3). This evidence concerns the gene EGFR and central nervous system cancer.