THBS2 and colorectal carcinoma: In addition, we also compared the the serum RBP4 and THBS2 concentrations and some high risk factors of CRC according to the definition by American Cancer Society [24] including the history of chronic diarrhea or constipation, the history of cholecystectomy or appendectomy and the history of CRC in family or Familial Adenomatous Polyps (FAP).