After excluding TNM stages, BMI and iFOBT by forward LR method, we found that tumor metastasis (HR: 4.375; 95% CI: 2.315-8.267; p<0.001), diabetes (HR: 2.514; 95% CI: 1.264-5.000; p=0.009) and RBP4 (HR: 0.409; 95% CI: 0.200-0.837; p=0.014) proved to be independent prognostic factors for survival in colorectal cancer (Table 2). This evidence concerns the gene RBP4 and diabetes mellitus.