In addition, we also compared the the serum RBP4 and THBS2 concentrations and some high risk factors of CRC according to the definition by American Cancer Society [24] including the history of chronic diarrhea or constipation, the history of cholecystectomy or appendectomy and the history of CRC in family or Familial Adenomatous Polyps (FAP). The gene discussed is RBP4; the disease is colorectal carcinoma.