CDKN2B and neoplasm: Intriguingly, this CDKN2A-CDKN2B cluster contains CDKN2B-AS1 (also known as ANRIL), a non-coding RNA transcribed in the antisense orientation of CDKN2A and CDKN2B. This non-coding RNA interacts with polycomb repressive complexes 1 and 2, leading to epigenetic repression of other tumor suppressor genes within the cluster, thereby facilitating tumor growth [18].