Moreover, our data with TLR7-8 as adjuvant to potentiate the innate immunity, as NK cells, aligns with the data that topical resiquimod, an agonist of TLR7/8, is safe and effective in patients with stage IA-IIA CTCL, that can clear both treated and untreated skin lesions [37]. The gene discussed is TLR7; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.