Previously we observed a dysfunctional cytokine response in the PBMCs of SS patients upon TLR agonists (TLR2-TLR9) stimulation, emphasizing the role of TLR7/8 agonists (CL097), which partially restored inflammatory cytokine and type I and type II interferon (IFN) secretion [41]. The gene discussed is TLR7; the disease is synovial sarcoma.