Here, we propose to investigate innate immunity in SS by evaluating NK cell subsets, activation/inhibitory receptor expression, soluble NKG2D ligand levels, “memory” phenotype NK cells, and the effector response induced by a TLR7/8 agonist and differentially expressed genes (DEGs) related to the TLR signaling pathway. Here, TLR7 is linked to synovial sarcoma.