Some hypertrophic TFs, such as myocyte enhancer factor 2 (MEF2), NK family of transcription factor 2.5 (Nkx2.5), GATA4, nuclear factor of activated T-cells (NFAT), and Ca2+/cAMP response element-binding protein (CREB) [14–16], have been known implicated as signal-responsive mediators of the cardiac transcriptional program in cardiac hypertrophy. The gene discussed is MEF2A; the disease is cardiac hypertrophy.