Further evidence to support that H19 and CUL4A are involved in the same molecular pathway comes from the analysis of gene expression profile and KEGG pathways in H19 and CUL4A knockdown breast cancer cells, in which seven molecular pathways affected by CUL4A knockdown in breast cancer cells are converged to those with H19 knockdown (Table 3). The gene discussed is CUL4A; the disease is breast cancer.