Moreover, this data is in agreement with previous reports that H19 lncRNA expression was increased in Dox-resistant liver cancer cells [21], paclitaxel-resistant breast cancer cell [34], cisplatin-resistant lung cancer cells [25], cisplatin-resistant ovarian cancer cells [25, 35], methotrexate-resistant colorectal cancer cells [36] temozolomide-resistant glioma cells [37] and tamoxifen-resistant breast cancer cells (our unpublished observation), which were shown to contribute to the drug resistance. Here, H19 is linked to central nervous system cancer.