ID3 and B-cell chronic lymphocytic leukemia: In lymphoid malignancies, although Nilsson et al. argued that ID2 was dispensable for MYC-induced lymphomagenesis [8], a recent study reported that ID2 and ID3 proteins had a pro-survival function in chronic lymphocytic leukemia cells and also highlighted these proteins as potential determinants of the pathobiology of chronic lymphocytic leukemia [9].