Interestingly, in our study not only the dual PI3K/mTOR inhibitor NVP-BEZ235 but also the selective inhibitor RAD001 improved the anti-tumor efficacy of NVP-BGJ398 treatment in both H1703 and LENTI-4 cells, underlining the relevance of mTOR inhibition for SQCLC. Here, MTOR is linked to neoplasm.