FGFR1 and large cell carcinoma: Comparable results, confirming the role of FGFR1 signaling in the regulation of glucose metabolism under normoxia and hypoxia, were obtained in the NSCLC large cell carcinoma H1581 cell line, a cell model that harbors focal amplification of FGFR1 and is highly sensitive to FGFR1 inhibition (not shown).