EFNB2 and neoplasm: Furthermore, we explored the role of ephrin-B2 in OSCC cells during tumor development and progression using in vitro and in vivo assays and found that overexpression of ephrin-B2 in OSCC cells and activation of ephrin-B2 reverse signaling pathway in the tumor microenvironment facilitated progression and lymph node metastasis via augmentation of malignant potential and interaction of OSCC cells with surrounding cells.