The modulation of Blcap function by A-to-I RNA editing also provides a suggestive mechanism to explain the bimodal effects we observed for Blcap in bladder cancer, and some of the challenging observations we made, concerning loss of expression of Blcap with bladder cancer progression, and the fact that tumors that expressed this protein at very high levels showed a worse prognosis. Here, BLCAP is linked to urinary bladder cancer.