PTP4A3 and pachyonychia congenita: As PRL-3 is a potential cancer biomarker and biomarkers in PC are in high demand, Exploring the expression and biological role of PRL-3 in PC cells, Vandsemb et al [22] found PRL-3 mRNA to be highly expressed in PC tissue compared to benign prostate tissue, and the PRL-3 protein was expressed in both primary PCs and regional lymphatic metastasis.