Activation of the cholinergic anti-inflammatory pathway using α7nAChRs agonists attenuates inflammation in several organs, including the kidneys during ischemia reperfusion injury [13, 16, 17] and septic-AKI [18], as well as other inflammatory conditions including experimental models of colitis [19], atherosclerosis [20], and sepsis [21]. The gene discussed is CHRNA7; the disease is acute kidney injury.