By detecting RNA level of LNX1 of the sorted SP and non-SP from the colorectal carcinoma cell line HT29, it was found that LNX1 was highly expressed in SP cells with higher levels of LGR5, ABCB5, ALDH1A1 and CD133 rather than non-SP group (Fig 1A, 1B and 1C). Here, LNX1 is linked to colorectal carcinoma.