Moreover, IgA, IgG, and IgM levels and the Igλ/Igκ ratio could accurately identify patients with nephritis (AUC = 0.86, confidence interval (CI) = 0.75–0.96, p<0.0001; AUC = 0.78, CI = 0.66–0.90, p = 0.001; AUC = 0.87, CI = 0.77–0.97, p<0.0001; and AUC = 0.75, CI = 0.59–0.90, p = 0.004, respectively; Fig 1E). The gene discussed is CD40LG; the disease is nephritis.