Noteworthy, TGF-β has not only been shown to be involved in glaucoma pathophysiology, but in recent years has also been linked to various other major ophthalmic diseases such as wet [47] and dry [30] AMD, diabetic retinopathy [48], proliferative vitreoretinopathy [49, 50], secondary cataract [51] and corneal disease [52]. This evidence concerns the gene TGFB1 and CAPN5-related vitreoretinopathy.