CXCL12 and carcinoma: We observed that SDF-1 expression in the injured tissues was statistically significant higher with respect to healthy ones, it could be indicating that SDF-1 could be recruitment our labelled MSCs (Fig 5C) and also could be recruiting naive MSCs from periosteum to bone repair sites as published Kitaori[29] These data were similar to published with other authors where found increasing of expression of this cytokine which had a key role in the homing of hematopoietic cells to marrow in carcinomas which had a remarkable tendency to invade bone [30].