Our group developed an efficient and reproducible procedure for the isolation of MSCs from synovial tissues of normal and osteoarthritis (OA) human donors based on the expression of the antigen CD105 and we demonstrated the cellular subset CD105+-MSCs posse chondrogenic capacity and also we demonstrated the similarity between CD105+-MSCs cultured from normal and OA synovial membranes reflected an absence of any effect from this pathological condition[1]. Here, ENG is linked to osteoarthritis.