Using the Δf derived features from TCGA, we further tested if our novel diffusion-based functional activity profile is predictive of known clinical characteristics of breast tumors, specifcially, the cancer subtype (Basal, Her2, Luminal A, Luminal B, Normal-like), and its hormone response status, Estrogen Receptor positive (ER+) and Progesterone Receptor positive (PR+). The gene discussed is ESR1; the disease is breast neoplasm.