We get a strong association signal when we test if the 12 breast oncogene drivers (AKT1, BRAF, EGFR, ERBB2, FLT3, IDH1, KLF4, KRAS, MED12, NRAS, PIK3CA and SF3B1) have a higher tendency to gain functions relative to the rest (AUC-ROC value = 0.737, p-value: 0.0025) whereas the 39 breast tumor suppressor drivers did not have a higher tendency to lose functions relative to the rest (AUC-ROC value = 0.51, p-value: 0.405). The gene discussed is KLF4; the disease is neoplasm.