Adipose tissue secretes proinflammatory adipokines [leptin, resistin, tumor necrosis factor alpha (TNF-α), interleukin 1 beta (Il-1β), and interleukin 6 (IL-6)], which contribute to a chronic low-grade inflammatory state and to metabolic disorders associated with cardiovascular disease, insulin resistance, and metabolic syndrome [1]. The gene discussed is TNF; the disease is metabolic disease.