REV3L and cancer: However, Pol ζ recruitment and control still needs to be thoroughly investigated, especially in conditions of increased Pol ζ involvement in DNA replication, which may lead to genetic instability and cancer (Knobel and Marti 2011; Lange et al. 2011, 2013; Skoneczna et al. 2015; van Loon et al. 2015; Korzhnev and Hadden 2016; Vaisman and Woodgate 2017; Zhao and Washington 2017).