In facioscapulohumeral muscular dystrophy (FSHD), local chromatine decompaction allows lncRNA-DBE-T transcription and therefore the recruitment of trithorax group protein of histone methyltransferase Ash1L, leading to activation of FSHD candidate genes [80]. The gene discussed is PRDM9; the disease is facioscapulohumeral muscular dystrophy.