Recent large genomic data analysis revealed 57 somatic co-mutations in NSCLC patients (n = 129) harboring EML4-ALK fusion protein; the top 10 co-mutated genes were: TP53, ARID1A, ATPX, NF1, NOTCH1, ROS1, ARID1B, CSF1R, ALK, APC, FLT3, NPM1, and SMAD4 [13]. Here, EML4 is linked to non-small cell lung carcinoma.