For example, T cells expressing a CAR incorporating a scFv of the ALK48 mAb linked to a 4-1BB-CD3ζ signaling domain elicited ALK-expressing tumor lysis and produced IFN-γ upon antigen stimulation, but limited anti-tumor efficacy was observed in xenograft models of human neuroblastoma [84]. The gene discussed is ALK; the disease is neuroblastoma.