RHOU and acute lymphoblastic leukemia: RhoU was also demonstrated to increase the adhesion and migration of osteoclast precursor cells.21 In NIH3T3 fibroblasts, activated RhoU resulted in a significant loss of focal adhesions.22 In HeLa cells, RhoU also localized to focal adhesions and promoted their disassembly during cell migration.20 Conversely, siRNA-mediated knockdown of RhoU resulted in the reduced adhesion of T-ALL cell lines to fibronectin and to endothelial cells.23 This indicates that the role of RhoU in cell-substratum or cell-cell adhesion is cell-type dependent.