TCF7L2 and prediabetes syndrome: However, the authors of one study demonstrated the cumulative role of several genetic variants linked to T2D (in genes TCF7L2, HHEX, SLC30A8, WFS1, KCNJ11, KCNQ1, MTNR1B, FTO and PPARG) in the development of prediabetes in adolescents.