TCF7L2 and prediabetes syndrome: A greater number of variants was associated with a higher likelihood of prediabetes in this population.16 In another study, the authors linked genetic variants in genes TCF7L2, IGF2BP2, CDKAL1 and HHEX1A with oral glucose tolerance test results in adolescents, identifying reduced insulin secretion as an important pathophysiologic factor.17 In the study of Xi et al.,18 two SNPs in or near the GNPDA2 and KCTD15 genes were significantly associated with the risk of IR in Chinese children.