The rs212540 SNP is located in an intron region of the endothelin converting enzyme 1 (ECE1) and has been associated with cardiovascular complications of diabetes,56 as well as with adult human height57 and childhood obesity-related traits in a Hispanic population.14 The rs3218888 SNP is located in an intron of the interleukin 1 receptor type 2 (IL1R2). The gene discussed is ECE1; the disease is obesity due to melanocortin 4 receptor deficiency.