Evaluation of MSI-specific tumours showed that two additional genes were downregulated, CARD11 and VCAM1 (FC 0.37 and 0.59, respectively) and six genes were upregulated (LYN FC 1.59, TICAM2 FC 1.64, ICAM1 FC 1.91, IL1B FC 2.06, CCL4 FC 2.72, and PTGS2 FC 3.23) that were statistically significant (Supplemental Table 3 for MSI-specific results). The gene discussed is ICAM1; the disease is neoplasm.