CETP and triple-A syndrome: Although the allele increases HDL-C levels, it is also associated with lower circulating concentrations of TG and LDL-C; thus, rs3764261 cannot be considered as an instrument for HDL-C in isolation but can be used to gauge insight into the potential associations with CETP inhibition.30 This HDL-raising CETP SNP was associated with lower AAA risk (OR per HDL-C–raising allele, 0.89; 95% CI, 0.85-0.94; P = 3.7 × 10−7).