PCSK9 and triple-A syndrome: A recent phase 3 clinical trial showed that PCSK9 inhibitors have beneficial effects on CVD outcomes.38 Although the association we found between PCSK9 variants and AAA was weak, if PSCK9 inhibitors do prove to be a safe and cost-effective means of lowering LDL-C levels, then consideration should be given to evaluating these drugs in patients with AAA.