PCSK9 and coronary artery disorder: To date, in CHD, genetic and clinical studies have had concordant results.33,38 We examined 2 independent SNPs in PCSK9 (rs2479409 and rs11206510; linkage disequilibrium r2 = 0.07) that were used as proxies for PCSK9 inhibition in a large-scale MR analysis39 and have strong, independent associations with both LDL-C levels and CHD.