Zinc-finger E-box-binding homeobox 1 (ZEB1) is a transcription factor that drives EMT and cancer progression, and its expression often follows activation of Snail expression.72,76 ZEB1 was highly expressed in GBC-invasive sites and increased the GBC-invasive potential by repressing E-cadherin and T-cadherin expression and increasing N-cadherin and Vimentin expression at the transcriptional level.57 Furthermore, ZEB1 levels were reduced by Forkhead box L1 overexpression to rescue E-cadherin expression and inhibit GBC cell migration and invasion.77 The gene discussed is CDH1; the disease is cancer.