The findings from this study revealed that, there is a general decline in the acid mucin expression as the adenocarcinomas of the colon progressed from low-grade cancer such as well-differentiated adenocarcinoma through moderately differentiated adenocarcinoma to the high grade poorly differentiated adenocarcinoma whilst there was an corresponding upsurge in the expression of neutral mucins. The gene discussed is MUC5AC; the disease is cancer.