The findings from this study revealed that, there is a general decline in the acid mucin expression as the adenocarcinomas of the colon progressed from low-grade cancer such as well-differentiated adenocarcinoma through moderately differentiated adenocarcinoma to the high grade poorly differentiated adenocarcinoma whilst there was an corresponding upsurge in the expression of neutral mucins. Here, MUC5AC is linked to adenocarcinoma.