PPARGC1A and type 2 diabetes mellitus: On the contrary, lowered PGC-1α expression was observed in diabetic human blood and myocardium (Fabregat-Andres et al., 2016) as well as in the animal models of T2DM (ob/ob mice) and diabetic dyslipidemia (db/db mice) (Buchanan et al., 2005).