There is a important decrease in SRF both in mRNA and protein levels as early as 5 days after tamoxifen; mice then progressively exhibit a decline of cardiac function, associated with reduced metabolic flux to the myofibril and decrease contractility, leading to dilated cardiomyopathy, HF, and death within 10 weeks (Parlakian et al., 2005). Here, SRF is linked to hydrops fetalis.