SRF and dilated cardiomyopathy: There is a important decrease in SRF both in mRNA and protein levels as early as 5 days after tamoxifen; mice then progressively exhibit a decline of cardiac function, associated with reduced metabolic flux to the myofibril and decrease contractility, leading to dilated cardiomyopathy, HF, and death within 10 weeks (Parlakian et al., 2005).