For this purpose, we selected a mouse model of non-ischemic DCM triggered by cardiac-specific inducible inactivation of the Serum Response Factor (SRF-HKO mice) (Parlakian et al., 2005; Diguet et al., 2011), a major regulator of cardiac genes and microRNAs that is repressed in human failing hearts (Davis et al., 2002; Chang et al., 2003). The gene discussed is SRF; the disease is familial dilated cardiomyopathy.