NPPA and hydrops fetalis: The functional efficiency of voluntary physical activity on cardiac function during the establishment of HF was further reinforced by a reduction in the expression of the stress-induced atrial natriuretic factor (p < 0.05) and brain natriuretic peptide (p < 0.01) in exercised SRF-HKO wheel group compared to sedentary SRF-HKO mice (Figure 1F).