DPP-4 inhibitors (HR, 0.761; 95% CI, 0.633–0.914; P = 0.004), dyslipidemia (HR, 0.718; 95% CI, 0.576–0.895; P = 0.003), and ACEI/ARBs (HR, 0.681; 95% CI, 0.511–0.908; P = 0.009) significantly reduced the risk of eGFR decline >20% (Figure 4B). The gene discussed is DPP4; the disease is metabolic syndrome.