To test the prediction of the single-cell model on the action of Numb as PSF for the hybrid E/M phenotype, we knocked down either Numb or Numb-like (Numbl) in non-small cell lung cancer (NSCLC) H1975 cells that display a stable hybrid E/M phenotype over many passages in vitro. The gene discussed is NUMBL; the disease is non-small cell lung carcinoma.