The target antigens are concentrated at nodes of Ranvier or at paranodes and are often cell adhesion molecules (CAMs) such as NrCAM, gliomedin, contactin-1, neurofascin (NF) 186, and NF155.1, –, 7 Immunoglobulin (Ig) G4 antibodies to NF155 or its binding partner, contactin, have been associated with severe CIDP resistant to IV immunoglobulin (IVIG) treatment but potentially responsive to rituximab.2,7,8. This evidence concerns the gene NFASC and chronic inflammatory demyelinating polyradiculoneuropathy.